8HIT
Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4
Summary for 8HIT
Entry DOI | 10.2210/pdb8hit/pdb |
Descriptor | JS007-VH, JS007-VL, Cytotoxic T-lymphocyte protein 4 (3 entities in total) |
Functional Keywords | complex, anti-body, scfv, immune system |
Biological source | Mus musculus More |
Total number of polymer chains | 3 |
Total formula weight | 37671.14 |
Authors | |
Primary citation | Guan, J.,Liu, H.,Chai, Y.,Yu, J.,Yao, J.,Wang, J.,Pan, Z.,Zhang, J.,Zhou, Y.,Liu, H.,Yao, S.,Qi, J.,Feng, H.,Gao, G.F.,Wang, Q.,Shi, Y.,Tan, S. Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer. Mabs, 15:2153409-2153409, 2023 Cited by PubMed: 36511654DOI: 10.1080/19420862.2022.2153409 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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