8HHU
Crystal structure of the SARS-CoV-2 main protease in complex with SY110
Summary for 8HHU
Entry DOI | 10.2210/pdb8hhu/pdb |
Descriptor | 3C-like proteinase nsp5, (1~{R})-3,3-bis(fluoranyl)-~{N}-[(2~{R})-3-methoxy-1-oxidanylidene-1-[[(2~{R},3~{S})-3-oxidanyl-4-oxidanylidene-1-phenyl-4-(1,3-thiazol-2-ylmethylamino)butan-2-yl]amino]propan-2-yl]cyclohexane-1-carboxamide (3 entities in total) |
Functional Keywords | severe acute respiratory syndrome coronavirus 2, main protease, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 1 |
Total formula weight | 34405.18 |
Authors | |
Primary citation | Huang, C.,Shuai, H.,Qiao, J.,Hou, Y.,Zeng, R.,Xia, A.,Xie, L.,Fang, Z.,Li, Y.,Yoon, C.,Huang, Q.,Hu, B.,You, J.,Quan, B.,Zhao, X.,Guo, N.,Zhang, S.,Ma, R.,Zhang, J.,Wang, Y.,Yang, R.,Zhang, S.,Nan, J.,Xu, H.,Wang, F.,Lei, J.,Chu, H.,Yang, S. A new generation M pro inhibitor with potent activity against SARS-CoV-2 Omicron variants. Signal Transduct Target Ther, 8:128-128, 2023 Cited by PubMed: 36928316DOI: 10.1038/s41392-023-01392-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.258 Å) |
Structure validation
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