8HHP

Crystal structure of PPARg-LBD complexed with three partial agonists, one nTZDpa and two LT175

Summary for 8HHP

Entry DOI	10.2210/pdb8hhp/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID, (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid, ... (4 entities in total)
Functional Keywords	pparg-lbd, partial agonists, ntzdpa, lt175, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32514.58
Authors	Kojima, H.,Itoh, T. (deposition date: 2022-11-16, release date: 2023-11-22, Last modification date: 2024-05-22)
Primary citation	Kojima, H.,Yanagi, R.,Higuchi, E.,Yoshizawa, M.,Shimodaira, T.,Kumagai, M.,Kyoya, T.,Sekine, M.,Egawa, D.,Ohashi, N.,Ishida, H.,Yamamoto, K.,Itoh, T. Covalent Modifier Discovery Using Hydrogen/Deuterium Exchange-Mass Spectrometry. J.Med.Chem., 66:4827-4839, 2023 Cited by PubMed: 36994595 DOI: 10.1021/acs.jmedchem.2c01986 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation