8HFJ

Crystal Structure of CbAR mutant (H162F) in complex with NADP+ and a bulky 1,3-cyclodiketone

Summary for 8HFJ

• Entry DOI: 10.2210/pdb8hfj/pdb
• Descriptor: Versicolorin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-methyl-2-[(4-methylphenyl)methyl]cyclopentane-1,3-dione, ... (4 entities in total)
• Functional Keywords: anthrol reductase, chiral alcohol, emodin, oxidoreductase
• Biological source: Cercospora sp. JNU001
• Total number of polymer chains: 4
• Total formula weight: 123905.93

Authors

Hou, X.D.,Yin, D.J.,Rao, Y.J. (deposition date: 2022-11-10, release date: 2023-06-07, Last modification date: 2023-11-08)

• Primary citation: Hou, X.,Xu, H.,Yuan, Z.,Deng, Z.,Fu, K.,Gao, Y.,Liu, C.,Zhang, Y.,Rao, Y.; Structural analysis of an anthrol reductase inspires enantioselective synthesis of enantiopure hydroxycycloketones and beta-halohydrins.; Nat Commun, 14:353-353, 2023; PubMed: 36681664; DOI: 10.1038/s41467-023-36064-4

Experimental method

X-RAY DIFFRACTION (2.75 Å)