8HFF

Cryo-EM structure of human norepinephrine transporter NET in the presence of norepinephrine in an inward-open state at resolution of 2.9 angstrom.

Summary for 8HFF

Entry DOI	10.2210/pdb8hff/pdb
Related	8HFE
EMDB information	34718 34719
Descriptor	Sodium-dependent noradrenaline transporter, L-NOREPINEPHRINE (3 entities in total)
Functional Keywords	norepinephrine transporter, net, slc6a2, norepinephrine, dopamine, neurotransmitter, desipramine, bupropion, antidepressant., transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	69724.90
Authors	Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C. (deposition date: 2022-11-10, release date: 2024-05-15, Last modification date: 2024-08-07)
Primary citation	Tan, J.,Xiao, Y.,Kong, F.,Zhang, X.,Xu, H.,Zhu, A.,Liu, Y.,Lei, J.,Tian, B.,Yuan, Y.,Yan, C. Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 2024 Cited by PubMed: 39048818 DOI: 10.1038/s41586-024-07719-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.86 Å)

Structure validation