8HF8

Human PPAR delta ligand binding domain in complex with a synthetic agonist V1

8HF8 の概要

• エントリーDOI: 10.2210/pdb8hf8/pdb
• 分子名称: Peroxisome proliferator-activated receptor delta, 2-[4-[[2,5-bis(oxidanylidene)-3-[4-(trifluoromethyl)phenyl]imidazolidin-1-yl]methyl]-2,6-dimethyl-phenoxy]-2-methyl-propanoic acid, octyl beta-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: complex, agonist, peroxisome proliferator-activated receptor, nuclear protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66234.81

構造登録者

Dai, L.,Sun, H.B.,Yuan, H.L.,Feng, Z.Q. (登録日: 2022-11-09, 公開日: 2023-09-06)

• 主引用文献: Feng, Z.,Xiang, J.,Sun, G.,Liu, H.,Wang, Y.,Liu, X.,Feng, J.,Xu, Q.,Wen, X.,Yuan, H.,Sun, H.,Dai, L.; Discovery of the First Subnanomolar PPAR alpha / delta Dual Agonist for the Treatment of Cholestatic Liver Diseases.; J.Med.Chem., 66:7331-7354, 2023; PubMed: 37243609; DOI: 10.1021/acs.jmedchem.2c02123

実験手法

X-RAY DIFFRACTION (2.11 Å)