8H7B

The crystal structure of human mcl1 kinase domain in complex with MCL1-M-EBA

8H7B の概要

• エントリーDOI: 10.2210/pdb8h7b/pdb
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, 7-[3-(isoquinolin-7-yloxymethyl)-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid (3 entities in total)
• 機能のキーワード: complex, inhibitor, lysine, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36011.04

構造登録者

Zhu, C.J.,Zhang, Z.M. (登録日: 2022-10-19, 公開日: 2023-02-22, 最終更新日: 2024-02-07)

• 主引用文献: Chen, P.,Tang, G.,Zhu, C.,Sun, J.,Wang, X.,Xiang, M.,Huang, H.,Wang, W.,Li, L.,Zhang, Z.M.,Gao, L.,Yao, S.Q.; 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.; J.Am.Chem.Soc., 2023; PubMed: 36774655; DOI: 10.1021/jacs.2c11595

実験手法

X-RAY DIFFRACTION (1.4640844632 Å)