8H7A

Crystal structure of the dimer form KAT6A WH domain with its bound double stranded DNA

8H7A の概要

• エントリーDOI: 10.2210/pdb8h7a/pdb
• 分子名称: Histone acetyltransferase KAT6A, DNA (5'-D(*GP*GP*TP*CP*CP*GP*AP*CP*GP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*CP*GP*TP*CP*GP*GP*AP*CP*C)-3'), ... (5 entities in total)
• 機能のキーワード: cpg islands, winged-helix domain, acetyltransferase, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 54626.41

構造登録者

Wang, Z.,Cao, Y. (登録日: 2022-10-19, 公開日: 2023-01-18, 最終更新日: 2023-11-29)

• 主引用文献: Weber, L.M.,Jia, Y.,Stielow, B.,Gisselbrecht, S.S.,Cao, Y.,Ren, Y.,Rohner, I.,King, J.,Rothman, E.,Fischer, S.,Simon, C.,Forne, I.,Nist, A.,Stiewe, T.,Bulyk, M.L.,Wang, Z.,Liefke, R.; The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.; Nucleic Acids Res., 51:574-594, 2023; PubMed: 36537216; DOI: 10.1093/nar/gkac1188

実験手法

X-RAY DIFFRACTION (1.92 Å)