8H78

Crystal structure of human MMP-2 catalytic domain in complex with inhibitor

8H78 の概要

• エントリーDOI: 10.2210/pdb8h78/pdb
• 分子名称: Matrix metalloproteinase-2, ZINC ION, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: gelatinase a, matrix metalloproteinase-2, 72 kda type iv collagenase, hydrolase
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40050.90

構造登録者

Kamitani, M.,Takeuchi, T.,Mima, M. (登録日: 2022-10-19, 公開日: 2023-01-18, 最終更新日: 2023-11-29)

• 主引用文献: Takeuchi, T.,Nomura, Y.,Tamita, T.,Nishikawa, R.,Kakinuma, H.,Kojima, N.,Hitaka, K.,Tamura, Y.,Kamitani, M.,Mima, M.,Nozoe, A.,Hayashi, M.; Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold.; J.Med.Chem., 66:822-836, 2023; PubMed: 36595440; DOI: 10.1021/acs.jmedchem.2c01698

実験手法

X-RAY DIFFRACTION (2.4 Å)