Loading
PDBj
メニューPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

8H73

Crystal structure of antibody scFv against M2e Influenza peptide

8H73 の概要
エントリーDOI10.2210/pdb8h73/pdb
関連するPDBエントリー8H3B
分子名称Single Chain Variable Fragment, CITRATE ANION (3 entities in total)
機能のキーワードscfv, antiviral protein
由来する生物種Homo sapiens
タンパク質・核酸の鎖数1
化学式量合計26945.78
構造登録者
Kumar, U.,Madni, Z.K.,Gaur, V.,Salunke, D.M. (登録日: 2022-10-18, 公開日: 2023-08-02, 最終更新日: 2024-10-23)
主引用文献Kumar, U.,Goyal, P.,Madni, Z.K.,Kamble, K.,Gaur, V.,Rajala, M.S.,Salunke, D.M.
A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein.
J.Biomed.Sci., 30:56-56, 2023
Cited by
PubMed Abstract: The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transmembrane viral M2 proton ion channel. M2 ectodomain (M2e) is a potential universal candidate for monoclonal antibody therapy owing to its conserved nature across influenza virus subtypes and its importance in viral propagation.
PubMed: 37491224
DOI: 10.1186/s12929-023-00950-2
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.91 Å)
構造検証レポート
Validation report summary of 8h73
検証レポート(詳細版)ダウンロードをダウンロード

239149

件を2025-07-23に公開中

PDB statisticsPDBj update infoContact PDBjnumon