8H6J

Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.

This is a non-PDB format compatible entry.

Summary for 8H6J

• Entry DOI: 10.2210/pdb8h6j/pdb
• Related: 8H6E
• EMDB information: 34500 34505
• Descriptor: pre-mRNA, U5 snRNA, Pre-mRNA-processing-splicing factor 8, ... (51 entities in total)
• Functional Keywords: exon-defined spliceosome, post pre-b state, splicing
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 61
• Total formula weight: 2735961.18

Authors

Zhang, W.,Zhan, X.,Zhang, X.,Lei, J.,Yan, C.,Shi, Y. (deposition date: 2022-10-18, release date: 2024-05-01, Last modification date: 2024-06-12)

• Primary citation: Zhang, W.,Zhang, X.,Zhan, X.,Bai, R.,Lei, J.,Yan, C.,Shi, Y.; Structural insights into human exon-defined spliceosome prior to activation.; Cell Res., 34:428-439, 2024; PubMed: 38658629; DOI: 10.1038/s41422-024-00949-w

Experimental method

ELECTRON MICROSCOPY (3.25 Å)