8H5T

Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-015

8H5T の概要

• エントリーDOI: 10.2210/pdb8h5t/pdb
• 分子名称: Spike protein S1, Nanobody Nb-015, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: viral protein, immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39004.55

構造登録者

Yang, J.,Lin, S.,Lu, G.W. (登録日: 2022-10-13, 公開日: 2023-10-18, 最終更新日: 2023-12-13)

• 主引用文献: Yang, J.,Lin, S.,Chen, Z.,Yang, F.,Guo, L.,Wang, L.,Duan, Y.,Zhang, X.,Dai, Y.,Yin, K.,Yu, C.,Yuan, X.,Sun, H.,He, B.,Cao, Y.,Ye, H.,Dong, H.,Liu, X.,Chen, B.,Li, J.,Zhao, Q.,Lu, G.; Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization.; Plos Pathog., 19:e1011804-e1011804, 2023; PubMed: 38033141; DOI: 10.1371/journal.ppat.1011804

実験手法

X-RAY DIFFRACTION (2 Å)