8GWK
SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP
Summary for 8GWK
Entry DOI | 10.2210/pdb8gwk/pdb |
EMDB information | 34314 |
Descriptor | RNA-directed RNA polymerase, MAGNESIUM ION, [(2~{R},3~{S},4~{R},5~{R})-5-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate, ... (12 entities in total) |
Functional Keywords | sars-cov-2, capping, nucleotide analogue inhibitor, cryo-em, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 More |
Total number of polymer chains | 9 |
Total formula weight | 323917.97 |
Authors | |
Primary citation | Yan, L.,Huang, Y.,Ge, J.,Liu, Z.,Lu, P.,Huang, B.,Gao, S.,Wang, J.,Tan, L.,Ye, S.,Yu, F.,Lan, W.,Xu, S.,Zhou, F.,Shi, L.,Guddat, L.W.,Gao, Y.,Rao, Z.,Lou, Z. A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185:4347-4360.e17, 2022 Cited by PubMed: 36335936DOI: 10.1016/j.cell.2022.09.037 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.72 Å) |
Structure validation
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