8GWH

PTPN21 PTP domain C1108S mutant in complex with SRC pTyr530 peptide

Summary for 8GWH

Entry DOI	10.2210/pdb8gwh/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 21, SRC pTyr530 peptide (3 entities in total)
Functional Keywords	ptpn21, phosphotase domain, ptp, ptpd1, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	35408.12
Authors	Chen, L.,Zheng, Y.Y.,Zhou, C. (deposition date: 2022-09-17, release date: 2023-09-20, Last modification date: 2024-04-17)
Primary citation	Chen, L.,Qian, Z.,Zheng, Y.,Zhang, J.,Sun, J.,Zhou, C.,Xiao, H. Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10:eadi7404-eadi7404, 2024 Cited by PubMed: 38416831 DOI: 10.1126/sciadv.adi7404 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation