8GVV
PTPN21 PTP domain C1108S mutant
Summary for 8GVV
Entry DOI | 10.2210/pdb8gvv/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 21, PHOSPHATE ION, IODIDE ION, ... (4 entities in total) |
Functional Keywords | ptpn21, phosphotase domain, ptp, ptpd1, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35140.15 |
Authors | Chen, L.,Zheng, Y.Y.,Zhou, C. (deposition date: 2022-09-15, release date: 2023-09-20, Last modification date: 2024-04-17) |
Primary citation | Chen, L.,Qian, Z.,Zheng, Y.,Zhang, J.,Sun, J.,Zhou, C.,Xiao, H. Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10:eadi7404-eadi7404, 2024 Cited by PubMed: 38416831DOI: 10.1126/sciadv.adi7404 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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