8GVJ

Crystal structure of cMET kinase domain bound by D6808

8GVJ の概要

• エントリーDOI: 10.2210/pdb8gvj/pdb
• 分子名称: Hepatocyte growth factor receptor, (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione (3 entities in total)
• 機能のキーワード: inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35400.87

構造登録者

Chen, Y.H.,Qu, L.Z. (登録日: 2022-09-15, 公開日: 2022-11-23, 最終更新日: 2023-11-29)

• 主引用文献: Wang, C.,Li, J.,Qu, L.,Tang, X.,Song, X.,Yang, F.,Chen, X.,Lin, Q.,Lin, W.,Zhou, Y.,Tu, Z.,Chen, Y.,Zhang, Z.,Lu, X.; Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.; J.Med.Chem., 65:15140-15164, 2022; PubMed: 36355693; DOI: 10.1021/acs.jmedchem.2c00981

実験手法

X-RAY DIFFRACTION (2.71 Å)