8GT3

Crystal structure of human cardiac alpha actin P109A mutant (ADP-Pi state) in complex with fragmin F1 domain

Summary for 8GT3

Entry DOI	10.2210/pdb8gt3/pdb
Descriptor	Actin, alpha cardiac muscle 1, Actin-binding protein fragmin P, ADENOSINE-5'-DIPHOSPHATE, ... (8 entities in total)
Functional Keywords	actin dynamics, atp hydrolysis, mutagenesis, md simulation, contractile protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	62936.81
Authors	Iwasa, M.,Oda, T.,Takeda, S. (deposition date: 2022-09-07, release date: 2023-03-08, Last modification date: 2023-11-29)
Primary citation	Iwasa, M.,Takeda, S.,Narita, A.,Maeda, Y.,Oda, T. Mutagenic analysis of actin reveals the mechanism of His161 flipping that triggers ATP hydrolysis. Front Cell Dev Biol, 11:1105460-1105460, 2023 Cited by PubMed: 37009486 DOI: 10.3389/fcell.2023.1105460 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation