8GRH
Crystal structure of a constitutively active mutant of the alpha gamma heterodimer of human IDH3 in complex with CIT
Summary for 8GRH
Entry DOI | 10.2210/pdb8grh/pdb |
Descriptor | Human IDH3 alpha subunit, Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, CITRIC ACID, ... (4 entities in total) |
Functional Keywords | isocitrate dehydrogenase, nad-dependent idh, assembly, allosteric regulation, oxidoreductase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 75684.77 |
Authors | |
Primary citation | Chen, X.,Sun, P.,Liu, Y.,Shen, S.,Ma, T.,Ding, J. Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction. J.Biol.Chem., 298:102695-102695, 2022 Cited by PubMed: 36375638DOI: 10.1016/j.jbc.2022.102695 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.506 Å) |
Structure validation
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