8GQ1
HyHEL10 Fab complexed with hen egg lysozyme carrying arginine cluster in framework region of light chain.
Summary for 8GQ1
Entry DOI | 10.2210/pdb8gq1/pdb |
Descriptor | Lysozyme C, Light Chain of HyHel10 Antibody Fragment (Fab), Heavy Chain of HyHel10 Antibody Fragment (Fab), ... (4 entities in total) |
Functional Keywords | engineered antibody, immune system |
Biological source | Mus musculus More |
Total number of polymer chains | 3 |
Total formula weight | 63490.59 |
Authors | Matsuura, H.,Hirata, K.,Sakai, N.,Nakakido, M.,Tsumoto, K. (deposition date: 2022-08-28, release date: 2023-08-30, Last modification date: 2024-03-13) |
Primary citation | Maeta, S.,Nakakido, M.,Matsuura, H.,Sakai, N.,Hirata, K.,Kuroda, D.,Fukunaga, A.,Tsumoto, K. Arginine cluster introduction on framework region in anti-lysozyme antibody improved association rate constant by changing conformational diversity of CDR loops. Protein Sci., 32:e4745-e4745, 2023 Cited by PubMed: 37550885DOI: 10.1002/pro.4745 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.13 Å) |
Structure validation
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