8GMB

Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible)

Summary for 8GMB

Entry DOI	10.2210/pdb8gmb/pdb
Descriptor	Tyrosine-protein kinase BTK, 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one (2 entities in total)
Functional Keywords	atp-binding, lipid-binding, transcription regulation, immunity, transferase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	1
Total formula weight	77065.14
Authors	Lin, D.Y.,Andreotti, A.H. (deposition date: 2023-03-24, release date: 2023-08-16, Last modification date: 2024-01-31)
Primary citation	Lin, D.Y.,Kueffer, L.E.,Juneja, P.,Wales, T.E.,Engen, J.R.,Andreotti, A.H. Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12:-, 2024 Cited by PubMed: 38189455 DOI: 10.7554/eLife.89489 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation