8GLA
Co-crystal structure of caPCNA bound to the AOH1996 derivative, AOH1996-1LE
Summary for 8GLA
Entry DOI | 10.2210/pdb8gla/pdb |
Descriptor | Proliferating cell nuclear antigen, N-[2-(3-methoxyphenoxy)phenyl]-N~2~-(naphthalene-1-carbonyl)-L-alpha-glutamine, CHLORIDE ION (3 entities in total) |
Functional Keywords | pcna, transcription-replication conflict, dna replication stress, dna repair, aoh1160, aoh1996, dna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 118457.79 |
Authors | Jossart, J.,Perry, J.J. (deposition date: 2023-03-21, release date: 2023-07-26, Last modification date: 2023-11-01) |
Primary citation | Gu, L.,Li, M.,Li, C.M.,Haratipour, P.,Lingeman, R.,Jossart, J.,Gutova, M.,Flores, L.,Hyde, C.,Kenjic, N.,Li, H.,Chung, V.,Li, H.,Lomenick, B.,Von Hoff, D.D.,Synold, T.W.,Aboody, K.S.,Liu, Y.,Horne, D.,Hickey, R.J.,Perry, J.J.P.,Malkas, L.H. Small molecule targeting of transcription-replication conflict for selective chemotherapy. Cell Chem Biol, 30:1235-, 2023 Cited by PubMed: 37531956DOI: 10.1016/j.chembiol.2023.07.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.77 Å) |
Structure validation
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