8GKT

Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF320 inhibitor

Summary for 8GKT

• Entry DOI: 10.2210/pdb8gkt/pdb
• Descriptor: Serine hydroxymethyltransferase, mitochondrial, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-{5-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]thiophene-2-carbonyl}-L-glutamic acid, ... (4 entities in total)
• Functional Keywords: shmt2, tetramer, glycine synthesis, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 110775.31

Authors

Katinas, J.M.,Dann III, C.E. (deposition date: 2023-03-20, release date: 2024-03-20)

• Primary citation: Katinas, J.M.,Nayeen, M.J.,Schneider, M.,Shah, K.,Fifer, A.N.,Klapper, L.M.,Sharma, A.,Thalluri, K.,Van Nieuwenhze, M.S.,Hou, Z.,Gangjee, A.,Matherly, L.H.,Dann 3rd, C.E.; Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.; Biochemistry, 2024; PubMed: 38324671; DOI: 10.1021/acs.biochem.3c00613

Experimental method

X-RAY DIFFRACTION (2.64 Å)