8GKJ

Crystal Structure of the Murine MUC16 Specific Antibody AR9.6

Summary for 8GKJ

• Entry DOI: 10.2210/pdb8gkj/pdb
• Descriptor: MUC16 antibody AR9.6 heavy chain, MUC16 antibody AR9.6 light chain (3 entities in total)
• Functional Keywords: antibody, fab, ca125, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 4
• Total formula weight: 98200.97

Authors

Brooks, C.L.,Aguilar, E.N. (deposition date: 2023-03-19, release date: 2024-03-20, Last modification date: 2024-10-02)

• Primary citation: Aguilar, E.N.,Sagar, S.,Murray, B.R.,Rajesh, C.,Lei, E.K.,Michaud, S.A.,Goodlett, D.R.,Caffrey, T.C.,Grandgenett, P.M.,Swanson, B.,Brooks, T.M.,Black, A.R.,van Faassen, H.,Hussack, G.,Henry, K.A.,Hollingsworth, M.A.,Brooks, C.L.,Radhakrishnan, P.; Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6.; Mol.Cancer Ther., 23:836-853, 2024; PubMed: 38394685; DOI: 10.1158/1535-7163.MCT-23-0868

Experimental method

X-RAY DIFFRACTION (1.9 Å)