8GK5

EGFR(T790M/V948R) kinase in complex with osimertinib and benzimidazole allosteric inhibitor

Summary for 8GK5

• Entry DOI: 10.2210/pdb8gk5/pdb
• Descriptor: Epidermal growth factor receptor, ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide, 2-[(R)-(1H-benzimidazol-2-yl)(3-fluorophenyl)methyl]-6-[4-(1-methylpiperidin-4-yl)phenyl]-2,3-dihydro-1H-isoindol-1-one, ... (4 entities in total)
• Functional Keywords: egfr, kinase, covalent, inhibitor, allosteric, cancer, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 155027.42

Authors

Beyett, T.S.,Eck, M.J. (deposition date: 2023-03-17, release date: 2024-06-26)

• Primary citation: Beyett, T.S.,Eck, M.J.; Development of benzimidazole allosteric EGFR kinase inhibitors; To be published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)