8GJT

Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with TFH-I-116-D1

Summary for 8GJT

Entry DOI	10.2210/pdb8gjt/pdb
Descriptor	HIV-1 LM/HT Clade A/E CRF01 gp120 core, 2-acetamido-2-deoxy-beta-D-glucopyranose, (3S)-N-(4-chloro-3-fluorophenyl)-1-[(3R,5S)-3,4,5-trimethylpiperazine-1-carbonyl]piperidine-3-carboxamide, ... (5 entities in total)
Functional Keywords	hiv-1 gp120, clade a/e cf01, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	1
Total formula weight	42363.50
Authors	Tolbert, W.D.,Nguyen, D.N.,Pazgier, M. (deposition date: 2023-03-16, release date: 2023-06-07)
Primary citation	Ding, S.,Tolbert, W.D.,Zhu, H.,Lee, D.,Marchitto, L.,Higgins, T.,Zhao, X.,Nguyen, D.,Sherburn, R.,Richard, J.,Gendron-Lepage, G.,Medjahed, H.,Mohammadi, M.,Abrams, C.,Pazgier, M.,Smith III, A.B.,Finzi, A. Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC. Viruses, 15:-, 2023 Cited by PubMed: 37243271 DOI: 10.3390/v15051185 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation