8GJH

Salmonella ArnA

Summary for 8GJH

• Entry DOI: 10.2210/pdb8gjh/pdb
• Related: 8FTN
• Descriptor: Bifunctional polymyxin resistance protein ArnA, URIDINE-5'-DIPHOSPHATE-GLUCURONIC ACID (2 entities in total)
• Functional Keywords: polymyxin resistance, udp-glucuronic acid decarboxylase, oxidoreductase
• Biological source: Salmonella enterica subsp. enterica serovar Typhimurium
• Total number of polymer chains: 6
• Total formula weight: 445536.73

Authors

Sousa, M.C.,Mitchell, M.E.,Gatzeva-Topalova, P.Z. (deposition date: 2023-03-15, release date: 2023-08-02, Last modification date: 2024-05-22)

• Primary citation: Mitchell, M.E.,Gatzeva-Topalova, P.Z.,Bargmann, A.D.,Sammakia, T.,Sousa, M.C.; Targeting the Conformational Change in ArnA Dehydrogenase for Selective Inhibition of Polymyxin Resistance.; Biochemistry, 62:2216-2227, 2023; PubMed: 37410993; DOI: 10.1021/acs.biochem.3c00227

Experimental method

X-RAY DIFFRACTION (3.6 Å)