8GIO

Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.1mM Mn2+

Summary for 8GIO

• Entry DOI: 10.2210/pdb8gio/pdb
• Descriptor: Cyclic GMP-AMP synthase, Palindromic DNA18, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: transferase-dna complex, cgas, atp and divalent metal ion, immune system, transferase/dna
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 108703.85

Authors

Wu, S.,Sohn, J. (deposition date: 2023-03-14, release date: 2024-04-17, Last modification date: 2024-05-29)

• Primary citation: Wu, S.,Gabelli, S.B.,Sohn, J.; The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.; Nat Commun, 15:4012-4012, 2024; PubMed: 38740774; DOI: 10.1038/s41467-024-48365-3

Experimental method

X-RAY DIFFRACTION (2.67 Å)