8GHR

Structure of human ENPP1 in complex with variable heavy domain VH27.2

8GHR の概要

• エントリーDOI: 10.2210/pdb8ghr/pdb
• EMDBエントリー: 40047
• 分子名称: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form, Immunoglobulin gamma-1 heavy chain fusion, VH27, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: phosphodiesterase, inhibitor, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 261723.97

構造登録者

Carozza, J.A.,Wang, H.,Solomon, P.E.,Wells, J.A.,Li, L. (登録日: 2023-03-10, 公開日: 2023-08-02, 最終更新日: 2024-01-03)

• 主引用文献: Solomon, P.E.,Bracken, C.J.,Carozza, J.A.,Wang, H.,Young, E.P.,Wellner, A.,Liu, C.C.,Sweet-Cordero, E.A.,Li, L.,Wells, J.A.; Discovery of VH domains that allosterically inhibit ENPP1.; Nat.Chem.Biol., 20:30-41, 2024; PubMed: 37400538; DOI: 10.1038/s41589-023-01368-5

実験手法

ELECTRON MICROSCOPY (3.2 Å)