8GHE

The structure of h12-LOX in tetrameric form bound to endogenous inhibitor oleoyl-CoA

8GHE の概要

• エントリーDOI: 10.2210/pdb8ghe/pdb
• EMDBエントリー: 40042
• 分子名称: Polyunsaturated fatty acid lipoxygenase ALOX12, FE (II) ION, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), ... (4 entities in total)
• 機能のキーワード: lipoxygenase, platelets, lipid-modifying enzyme, lipid oxidation, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 307586.17

構造登録者

Black, K.A.,Mobbs, J.I.,Venugopal, H.,Thal, D.M.,Glukhova, A. (登録日: 2023-03-09, 公開日: 2023-08-09, 最終更新日: 2023-10-11)

• 主引用文献: Mobbs, J.I.,Black, K.A.,Tran, M.,Burger, W.A.C.,Venugopal, H.,Holman, T.R.,Holinstat, M.,Thal, D.M.,Glukhova, A.; Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.; Blood, 142:1233-1242, 2023; PubMed: 37506345; DOI: 10.1182/blood.2023020441

実験手法

ELECTRON MICROSCOPY (2.05 Å)