8GHC
The structure of h12-LOX in dimeric form
Summary for 8GHC
Entry DOI | 10.2210/pdb8ghc/pdb |
EMDB information | 40040 40299 40300 40301 |
Descriptor | Polyunsaturated fatty acid lipoxygenase ALOX12, FE (II) ION (2 entities in total) |
Functional Keywords | lipoxygenase, platelets, lipid-modifying enzyme, lipid oxidation, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 153277.10 |
Authors | Black, K.A.,Mobbs, J.I.,Venugopal, H.,Thal, D.M.,Glukhova, A. (deposition date: 2023-03-09, release date: 2023-08-09, Last modification date: 2023-10-11) |
Primary citation | Mobbs, J.I.,Black, K.A.,Tran, M.,Burger, W.A.C.,Venugopal, H.,Holman, T.R.,Holinstat, M.,Thal, D.M.,Glukhova, A. Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors. Blood, 142:1233-1242, 2023 Cited by PubMed: 37506345DOI: 10.1182/blood.2023020441 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.3 Å) |
Structure validation
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