8GFA

Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791

8GFA の概要

• エントリーDOI: 10.2210/pdb8gfa/pdb
• 関連するPDBエントリー: 8GF8 8GF9
• EMDBエントリー: 29981 29982 29983
• 分子名称: Transient receptor potential cation channel subfamily V member 1, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide, ... (6 entities in total)
• 機能のキーワード: transient receptor potential v family member 1, trp, human, channel, inhibition, antagonist, trpv1, trp channels, pain, analgesic, drug, membrane protein, sb-366791, thermo-trp, temperature sensation, vanilloid, gdn, detergent, glyco-diosgenin
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 528927.81

構造登録者

Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (登録日: 2023-03-07, 公開日: 2023-05-10)

• 主引用文献: Neuberger, A.,Oda, M.,Nikolaev, Y.A.,Nadezhdin, K.D.,Gracheva, E.O.,Bagriantsev, S.N.,Sobolevsky, A.I.; Human TRPV1 structure and inhibition by the analgesic SB-366791.; Nat Commun, 14:2451-2451, 2023; PubMed: 37117175; DOI: 10.1038/s41467-023-38162-9

実験手法

ELECTRON MICROSCOPY (2.29 Å)