8GEQ

E. eligens beta-glucuronidase bound to ceritinib-glucuronide

8GEQ の概要

• エントリーDOI: 10.2210/pdb8geq/pdb
• 分子名称: Beta-glucuronidase, 4-amino-5-chloro-2-{4-(1-beta-D-glucopyranuronosylpiperidin-4-yl)-5-methyl-2-[(propan-2-yl)oxy]anilino}pyrimidine (3 entities in total)
• 機能のキーワード: beta-glucuronidase, inhibitor, glucuronide, hydrolase
• 由来する生物種: Lachnospira eligens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 70387.14

構造登録者

Simpson, J.B.,Kowalewski, M.K.,Redinbo, M.R. (登録日: 2023-03-07, 公開日: 2024-02-14, 最終更新日: 2024-09-04)

• 主引用文献: Simpson, J.B.,Walker, M.E.,Sekela, J.J.,Ivey, S.M.,Jariwala, P.B.,Storch, C.M.,Kowalewski, M.E.,Graboski, A.L.,Lietzan, A.D.,Walton, W.G.,Davis, K.A.,Cloer, E.W.,Borlandelli, V.,Hsiao, Y.C.,Roberts, L.R.,Perlman, D.H.,Liang, X.,Overkleeft, H.S.,Bhatt, A.P.,Lu, K.,Redinbo, M.R.; Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.; Cell Host Microbe, 32:925-944.e10, 2024; PubMed: 38754417; DOI: 10.1016/j.chom.2024.04.018

実験手法

X-RAY DIFFRACTION (2.75 Å)