8GB5

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 25F9

8GB5 の概要

• エントリーDOI: 10.2210/pdb8gb5/pdb
• 分子名称: Spike protein S1, 25F9 Heavy chain, 25F9 Light chain, ... (10 entities in total)
• 機能のキーワード: covid-19, sars-cov-2, antibody, spike, receptor binding domain, immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 286984.43

構造登録者

Yuan, M.,Zhu, X.,Wilson, I.A. (登録日: 2023-02-24, 公開日: 2023-05-24)

• 主引用文献: Feng, Y.,Yuan, M.,Powers, J.M.,Hu, M.,Munt, J.E.,Arunachalam, P.S.,Leist, S.R.,Bellusci, L.,Kim, J.,Sprouse, K.R.,Adams, L.E.,Sundaramurthy, S.,Zhu, X.,Shirreff, L.M.,Mallory, M.L.,Scobey, T.D.,Moreno, A.,O'Hagan, D.T.,Kleanthous, H.,Villinger, F.J.,Veesler, D.,King, N.P.,Suthar, M.S.,Khurana, S.,Baric, R.S.,Wilson, I.A.,Pulendran, B.; Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine.; Sci Transl Med, 15:eadg7404-eadg7404, 2023; PubMed: 37163615; DOI: 10.1126/scitranslmed.adg7404

実験手法

X-RAY DIFFRACTION (3.35 Å)