8G44
Structure of HDAC6 zinc-finger ubiquitin binding domain in complex with 3-(3-(2-(benzylamino)-2-oxoethyl)-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid
Summary for 8G44
Entry DOI | 10.2210/pdb8g44/pdb |
Descriptor | Histone deacetylase 6, ZINC ION, 3-{3-[2-(benzylamino)-2-oxoethyl]-4-oxo-3,4-dihydroquinazolin-2-yl}propanoic acid, ... (4 entities in total) |
Functional Keywords | inhibitor, chemical probe, hdac6, histone deacetylase, hydrolase, structural genomics, structural genomics consortium, sgc, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 12494.22 |
Authors | Harding, R.J.,Franzoni, I.,Mann, M.K.,Szewczyk, M.,Mirabi, B.,Owens, D.D.G.,Ackloo, S.,Scheremetjew, A.,Juarez-Ornelas, K.A.,Sanichar, R.,Baker, R.J.,Dank, C.,Brown, P.J.,Barsyte-Lovejoy, D.,Santhakumar, V.,Schapira, M.,Lautens, M.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (deposition date: 2023-02-08, release date: 2023-05-03, Last modification date: 2023-08-16) |
Primary citation | Harding, R.J.,Franzoni, I.,Mann, M.K.,Szewczyk, M.M.,Mirabi, B.,Ferreira de Freitas, R.,Owens, D.D.G.,Ackloo, S.,Scheremetjew, A.,Juarez-Ornelas, K.A.,Sanichar, R.,Baker, R.J.,Dank, C.,Brown, P.J.,Barsyte-Lovejoy, D.,Santhakumar, V.,Schapira, M.,Lautens, M.,Arrowsmith, C.H. Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6. J.Med.Chem., 66:10273-10288, 2023 Cited by PubMed: 37499118DOI: 10.1021/acs.jmedchem.3c00314 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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