8G3U
MBP-Mcl1 in complex with ligand 21
Summary for 8G3U
Entry DOI | 10.2210/pdb8g3u/pdb |
Related PRD ID | PRD_900001 |
Descriptor | Maltodextrin-binding protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | myeloid cell leukemia 1, mcl-1, b-cell lymphoma 2, bcl-2, bh3 mimetic, protein-protein interaction, modulator, apoptosis, cancer, leukemia, myeloma, lymphoma, physicochemical properties, adme properties, cardiotoxicity, therapeutic window |
Biological source | Serratia sp. FS14 More |
Total number of polymer chains | 1 |
Total formula weight | 58578.72 |
Authors | Miller, B.R.,Shaffer, P. (deposition date: 2023-02-08, release date: 2023-05-17, Last modification date: 2024-05-22) |
Primary citation | Romanov-Michailidis, F.,Hsiao, C.C.,Urner, L.M.,Jerhaoui, S.,Surkyn, M.,Miller, B.,Vos, A.,Dominguez Blanco, M.,Bueters, R.,Vinken, P.,Bekkers, M.,Walker, D.,Pietrak, B.,Eyckmans, W.,Dores-Sousa, J.L.,Joo Koo, S.,Lento, W.,Bauser, M.,Philippar, U.,Rombouts, F.J.R. Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies. J.Med.Chem., 66:6122-6148, 2023 Cited by PubMed: 37114951DOI: 10.1021/acs.jmedchem.2c01953 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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