8G2O

Fab structure - Anti-ApoE-7C11 antibody

Summary for 8G2O

• Entry DOI: 10.2210/pdb8g2o/pdb
• Descriptor: anti-ApoE-7C11 heavy chain, anti-ApoE-7C11 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: antibody, apoe, fab, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 48542.82

Authors

Marino, C.,Arboleda-Velasquez, J.F. (deposition date: 2023-02-06, release date: 2023-10-18, Last modification date: 2024-02-28)

Primary citation

Marino, C.,Perez-Corredor, P.,O'Hare, M.,Heuer, A.,Chmielewska, N.,Gordon, H.,Chandrahas, A.S.,Gonzalez-Buendia, L.,Delgado-Tirado, S.,Doan, T.H.,Vanderleest, T.E.,Arevalo-Alquichire, S.,Obar, R.A.,Ortiz-Cordero, C.,Villegas, A.,Sepulveda-Falla, D.,Kim, L.A.,Lopera, F.,Mahley, R.,Huang, Y.,Quiroz, Y.T.,Arboleda-Velasquez, J.F.
APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.
Alzheimers Dement, 20:819-836, 2024

PubMed Abstract: We discovered that the APOE3 Christchurch (APOE3Ch) variant may provide resistance to Alzheimer's disease (AD). This resistance may be due to reduced pathological interactions between ApoE3Ch and heparan sulfate proteoglycans (HSPGs).

PubMed: 37791598
DOI: 10.1002/alz.13436

Experimental method

X-RAY DIFFRACTION (1.7 Å)