8G2O

Fab structure - Anti-ApoE-7C11 antibody

8G2O の概要

• エントリーDOI: 10.2210/pdb8g2o/pdb
• 分子名称: anti-ApoE-7C11 heavy chain, anti-ApoE-7C11 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: antibody, apoe, fab, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48542.82

構造登録者

Marino, C.,Arboleda-Velasquez, J.F. (登録日: 2023-02-06, 公開日: 2023-10-18, 最終更新日: 2024-02-28)

主引用文献

Marino, C.,Perez-Corredor, P.,O'Hare, M.,Heuer, A.,Chmielewska, N.,Gordon, H.,Chandrahas, A.S.,Gonzalez-Buendia, L.,Delgado-Tirado, S.,Doan, T.H.,Vanderleest, T.E.,Arevalo-Alquichire, S.,Obar, R.A.,Ortiz-Cordero, C.,Villegas, A.,Sepulveda-Falla, D.,Kim, L.A.,Lopera, F.,Mahley, R.,Huang, Y.,Quiroz, Y.T.,Arboleda-Velasquez, J.F.
APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.
Alzheimers Dement, 20:819-836, 2024

PubMed Abstract: We discovered that the APOE3 Christchurch (APOE3Ch) variant may provide resistance to Alzheimer's disease (AD). This resistance may be due to reduced pathological interactions between ApoE3Ch and heparan sulfate proteoglycans (HSPGs).

PubMed: 37791598
DOI: 10.1002/alz.13436

実験手法

X-RAY DIFFRACTION (1.7 Å)