8G2F

Crystal Structure of PRMT3 with Compound II710

8G2F の概要

• エントリーDOI: 10.2210/pdb8g2f/pdb
• 分子名称: Protein arginine N-methyltransferase 3, 5'-S-[3-(N'-benzylcarbamimidamido)propyl]-5'-thioadenosine (3 entities in total)
• 機能のキーワード: prmt3, ii710, transferase, structural genomics, psi-2, protein structure initiative, structural genomics consortium, sgc, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38754.48

構造登録者

Song, X.,Dong, A.,Deng, Y.,Huang, R.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (登録日: 2023-02-03, 公開日: 2023-05-10, 最終更新日: 2024-02-21)

• 主引用文献: Deng, Y.,Song, X.,Iyamu, I.D.,Dong, A.,Min, J.,Huang, R.; A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors.; Acta Pharm Sin B, 13:4893-4905, 2023; PubMed: 38045046; DOI: 10.1016/j.apsb.2023.07.022

実験手法

X-RAY DIFFRACTION (2.06 Å)