8G1V
Crystal Structure Matriptase (C731S) in Complex with Inhibitor MM1132-2
Summary for 8G1V
Entry DOI | 10.2210/pdb8g1v/pdb |
Descriptor | Suppressor of tumorigenicity 14 protein, SULFATE ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | matriptase, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 27805.15 |
Authors | Lovell, S.,Kashipathy, M.M.,Battaile, K.P.,Janetka, J.W. (deposition date: 2023-02-03, release date: 2024-07-10, Last modification date: 2024-08-14) |
Primary citation | Mahoney, M.W.,Helander, J.,Kooner, A.S.,Norman, M.,Damalanka, V.C.,De Bona, P.,Kasperkiewicz, P.,Rut, W.,Poreba, M.,Kashipathy, M.M.,Battaile, K.P.,Lovell, S.,O'Donoghue, A.J.,Craik, C.S.,Drag, M.,Janetka, J.W. Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin. Protein Sci., 33:e5110-e5110, 2024 Cited by PubMed: 39073183DOI: 10.1002/pro.5110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
Download full validation report