8G1V

Crystal Structure Matriptase (C731S) in Complex with Inhibitor MM1132-2

8G1V の概要

• エントリーDOI: 10.2210/pdb8g1v/pdb
• 分子名称: Suppressor of tumorigenicity 14 protein, SULFATE ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: matriptase, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27805.15

構造登録者

Lovell, S.,Kashipathy, M.M.,Battaile, K.P.,Janetka, J.W. (登録日: 2023-02-03, 公開日: 2024-07-10, 最終更新日: 2024-08-14)

• 主引用文献: Mahoney, M.W.,Helander, J.,Kooner, A.S.,Norman, M.,Damalanka, V.C.,De Bona, P.,Kasperkiewicz, P.,Rut, W.,Poreba, M.,Kashipathy, M.M.,Battaile, K.P.,Lovell, S.,O'Donoghue, A.J.,Craik, C.S.,Drag, M.,Janetka, J.W.; Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.; Protein Sci., 33:e5110-e5110, 2024; PubMed: 39073183; DOI: 10.1002/pro.5110

実験手法

X-RAY DIFFRACTION (1.35 Å)