8G18

Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108

8G18 の概要

• エントリーDOI: 10.2210/pdb8g18/pdb
• 分子名称: Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2B, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: nmdar, amino-terminal domain, allosteric inhibitor, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor
• 由来する生物種: Xenopus laevis (African clawed frog); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 170548.91

構造登録者

Regan, M.C.,Furukawa, H. (登録日: 2023-02-01, 公開日: 2023-03-01, 最終更新日: 2023-10-25)

• 主引用文献: Harris, L.D.,Regan, M.C.,Myers, S.J.,Nocilla, K.A.,Akins, N.S.,Tahirovic, Y.A.,Wilson, L.J.,Dingledine, R.,Furukawa, H.,Traynelis, S.F.,Liotta, D.C.; Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.; Acs Chem Neurosci, 14:917-935, 2023; PubMed: 36779874; DOI: 10.1021/acschemneuro.2c00779

実験手法

X-RAY DIFFRACTION (2.85 Å)