8FXC

SARS-CoV-2 BQ.1.1 spike RBD bound to the human ACE2 ectodomain and the S309 neutralizing antibody Fab fragment

Summary for 8FXC

• Entry DOI: 10.2210/pdb8fxc/pdb
• EMDB information: 29531
• Descriptor: S309 Light chain, S309 Heavy chain, Processed angiotensin-converting enzyme 2, ... (7 entities in total)
• Functional Keywords: sars-cov-2, covid-19, bq.1.1, spike glycoprotein, neutralizing antibodies, structural genomics, seattle structural genomics center for infectious disease, ssgcid, inhibitor, ace2, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 177596.08

Authors

Park, Y.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID),Veesler, D. (deposition date: 2023-01-24, release date: 2023-10-04)

• Primary citation: Addetia, A.,Piccoli, L.,Case, J.B.,Park, Y.J.,Beltramello, M.,Guarino, B.,Dang, H.,de Melo, G.D.,Pinto, D.,Sprouse, K.,Scheaffer, S.M.,Bassi, J.,Silacci-Fregni, C.,Muoio, F.,Dini, M.,Vincenzetti, L.,Acosta, R.,Johnson, D.,Subramanian, S.,Saliba, C.,Giurdanella, M.,Lombardo, G.,Leoni, G.,Culap, K.,McAlister, C.,Rajesh, A.,Dellota Jr., E.,Zhou, J.,Farhat, N.,Bohan, D.,Noack, J.,Chen, A.,Lempp, F.A.,Quispe, J.,Kergoat, L.,Larrous, F.,Cameroni, E.,Whitener, B.,Giannini, O.,Cippa, P.,Ceschi, A.,Ferrari, P.,Franzetti-Pellanda, A.,Biggiogero, M.,Garzoni, C.,Zappi, S.,Bernasconi, L.,Kim, M.J.,Rosen, L.E.,Schnell, G.,Czudnochowski, N.,Benigni, F.,Franko, N.,Logue, J.K.,Yoshiyama, C.,Stewart, C.,Chu, H.,Bourhy, H.,Schmid, M.A.,Purcell, L.A.,Snell, G.,Lanzavecchia, A.,Diamond, M.S.,Corti, D.,Veesler, D.; Neutralization, effector function and immune imprinting of Omicron variants.; Nature, 621:592-601, 2023; PubMed: 37648855; DOI: 10.1038/s41586-023-06487-6

Experimental method

ELECTRON MICROSCOPY (3.2 Å)