8FWV
Structure of the amino-terminal domain of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and noncompetitive inhibitor perampanel
Summary for 8FWV
Entry DOI | 10.2210/pdb8fwv/pdb |
EMDB information | 29520 |
Descriptor | Glutamate receptor ionotropic, kainate 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | iglur, kainate receptor, positive allosteric modulator, perampanel, membrane protein |
Biological source | Rattus norvegicus (Norway rat) |
Total number of polymer chains | 4 |
Total formula weight | 415853.34 |
Authors | Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I. (deposition date: 2023-01-23, release date: 2023-04-19) |
Primary citation | Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I. Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Cell Rep, 42:112124-112124, 2023 Cited by PubMed: 36857176DOI: 10.1016/j.celrep.2023.112124 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.03 Å) |
Structure validation
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