8FWV

Structure of the amino-terminal domain of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and noncompetitive inhibitor perampanel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2752
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:8163463

Chain	Residue	Details
A	THR32-PRO561
A	THR660-ASN819
B	THR32-PRO561
B	THR660-ASN819
C	THR32-PRO561
C	THR660-ASN819
D	THR32-PRO561
D	THR660-ASN819

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ASP562-ALA582
D	ASP562-ALA582
D	ILE639-LEU659
D	ILE820-GLY840
A	ILE639-LEU659
A	ILE820-GLY840
B	ASP562-ALA582
B	ILE639-LEU659
B	ILE820-GLY840
C	ASP562-ALA582
C	ILE639-LEU659
C	ILE820-GLY840

---

site_id	SWS_FT_FI3
Number of Residues	488
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:8163463

Chain	Residue	Details
A	ARG583-GLY638
A	GLU841-ALA908
B	ARG583-GLY638
B	GLU841-ALA908
C	ARG583-GLY638
C	GLU841-ALA908
D	ARG583-GLY638
D	GLU841-ALA908

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:15721240, ECO:0000269|PubMed:17115050, ECO:0007744|PDB:1S50, ECO:0007744|PDB:1S7Y, ECO:0007744|PDB:2I0B, ECO:0007744|PDB:2I0C

Chain	Residue	Details
A	PRO516
B	ALA689
B	THR690
B	GLU738
C	PRO516
C	ALA518
C	ARG523
C	ALA689
C	THR690
C	GLU738
D	PRO516
A	ALA518
D	ALA518
D	ARG523
D	ALA689
D	THR690
D	GLU738
A	ARG523
A	ALA689
A	THR690
A	GLU738
B	PRO516
B	ALA518
B	ARG523

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q13002

Chain	Residue	Details
A	SER846
A	SER868
B	SER846
B	SER868
C	SER846
C	SER868
D	SER846
D	SER868

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21791290

Chain	Residue	Details
A	ASN67
D	ASN67
D	ASN378
D	ASN412
A	ASN378
A	ASN412
B	ASN67
B	ASN378
B	ASN412
C	ASN67
C	ASN378
C	ASN412

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN73
C	ASN275
C	ASN430
C	ASN546
D	ASN73
D	ASN275
D	ASN430
D	ASN546
A	ASN275
A	ASN430
A	ASN546
B	ASN73
B	ASN275
B	ASN430
B	ASN546
C	ASN73

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15677325

Chain	Residue	Details
A	ASN423
B	ASN423
C	ASN423
D	ASN423

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15677325, ECO:0000269|PubMed:8163463

Chain	Residue	Details
A	ASN751
B	ASN751
C	ASN751
D	ASN751

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000269|PubMed:17486098

Chain	Residue	Details
A	LYS886
B	LYS886
C	LYS886
D	LYS886

---