8FVU
Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)
Summary for 8FVU
Entry DOI | 10.2210/pdb8fvu/pdb |
EMDB information | 29493 |
Descriptor | Baculoviral IAP repeat-containing protein 1, NLR family CARD domain-containing protein 4, Lethal factor,Type III secretion system protein, ... (5 entities in total) |
Functional Keywords | nlrc4, naip, inflammasome, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 320960.13 |
Authors | Matico, R.E.,Yu, X.,Miller, R.,Somani, S.,Ricketts, M.D.,Kumar, N.,Steele, R.A.,Medley, Q.,Berger, S.,Faustin, B.,Sharma, S. (deposition date: 2023-01-19, release date: 2024-01-03, Last modification date: 2024-01-31) |
Primary citation | Matico, R.E.,Yu, X.,Miller, R.,Somani, S.,Ricketts, M.D.,Kumar, N.,Steele, R.A.,Medley, Q.,Berger, S.,Faustin, B.,Sharma, S. Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing. Nat.Struct.Mol.Biol., 31:82-91, 2024 Cited by PubMed: 38177670DOI: 10.1038/s41594-023-01143-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
Download full validation report