8FV7

E coli. CTP synthase in complex with dF-dCTP + ATP

This is a non-PDB format compatible entry.

Summary for 8FV7

• Entry DOI: 10.2210/pdb8fv7/pdb
• Descriptor: CTP synthase, ADENOSINE-5'-TRIPHOSPHATE, SODIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor complex, metabolic enzyme, cytosolic protein, ligase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 123006.56

Authors

Holyoak, T.,McLeod, M.J.,Tran, N. (deposition date: 2023-01-18, release date: 2023-05-24, Last modification date: 2023-10-25)

• Primary citation: McLeod, M.J.,Tran, N.,McCluskey, G.D.,Gillis, T.D.,Bearne, S.L.,Holyoak, T.; A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.; Protein Sci., 32:e4648-e4648, 2023; PubMed: 37106216; DOI: 10.1002/pro.4648

Experimental method

X-RAY DIFFRACTION (2.08 Å)