8FS1
CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11a (YD905)
Summary for 8FS1
Entry DOI | 10.2210/pdb8fs1/pdb |
Descriptor | Site-specific DNA-methyltransferase (adenine-specific), DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | dna adenine methylation, protein-dna complex, transferase, dna binding protein, transferase-dna-inhibitor complex, transferase/dna/inhibitor |
Biological source | Clostridioides difficile More |
Total number of polymer chains | 9 |
Total formula weight | 234457.57 |
Authors | Zhou, J.,Horton, J.R.,Cheng, X. (deposition date: 2023-01-09, release date: 2023-05-10, Last modification date: 2024-05-22) |
Primary citation | Zhou, J.,Deng, Y.,Iyamu, I.D.,Horton, J.R.,Yu, D.,Hajian, T.,Vedadi, M.,Rotili, D.,Mai, A.,Blumenthal, R.M.,Zhang, X.,Huang, R.,Cheng, X. Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase. Acs Chem.Biol., 18:734-745, 2023 Cited by PubMed: 37082867DOI: 10.1021/acschembio.3c00035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.74 Å) |
Structure validation
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