8FRI
LSD1-CoREST in complex with AW4, short soaking
Summary for 8FRI
Entry DOI | 10.2210/pdb8fri/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3S,3aS,13R)-1-hydroxy-10,11-dimethyl-4,6-dioxo-3-([1~1~,2~1~:2~3~,3~1~-terphenyl]-1~4~-yl)-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (non-preferred name) (3 entities in total) |
Functional Keywords | epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 112583.29 |
Authors | |
Primary citation | Caroli, J.,Mattevi, A. Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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