8FPX

Crystal structure of tumor related RhoA mutant A161P in complex with GDP

Summary for 8FPX

• Entry DOI: 10.2210/pdb8fpx/pdb
• Related: 8FPW
• Descriptor: Transforming protein RhoA, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: small g proteins, gtpase, fast-cycling mutant, a161p, signaling protein, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 21160.17

Authors

Lin, Y.,Zheng, Y. (deposition date: 2023-01-05, release date: 2024-06-05, Last modification date: 2024-09-04)

• Primary citation: Lin, Y.,Ramelot, T.A.,Senyuz, S.,Gursoy, A.,Jang, H.,Nussinov, R.,Keskin, O.,Zheng, Y.; Tumor-derived RHOA mutants interact with effectors in the GDP-bound state.; Nat Commun, 15:7176-7176, 2024; PubMed: 39169042; DOI: 10.1038/s41467-024-51445-z

Experimental method

X-RAY DIFFRACTION (1.47 Å)