8FPJ
Co-structure of the Human Metapneunomovirus RNA-dependent RNA polymerase with MRK-1
Summary for 8FPJ
Entry DOI | 10.2210/pdb8fpj/pdb |
EMDB information | 29366 |
Descriptor | RNA-directed RNA polymerase L, Phosphoprotein, 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide (3 entities in total) |
Functional Keywords | rna-binding protein, hmpv, rdrp, rna-dependent rna polymerase, prntase, polyribonucleotidyl transferase, rna capping, viral replication, viral protein, replication |
Biological source | Human metapneumovirus More |
Total number of polymer chains | 5 |
Total formula weight | 374961.97 |
Authors | Fischmann, T.O. (deposition date: 2023-01-04, release date: 2023-06-14, Last modification date: 2024-06-19) |
Primary citation | Kleiner, V.A.,Fischmann, T.O.,Howe, J.A.,Beshore, D.C.,Eddins, M.J.,Hou, Y.,Mayhood, T.,Klein, D.,Nahas, D.D.,Lucas, B.J.,Xi, H.,Murray, E.,Ma, D.Y.,Getty, K.,Fearns, R. Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Commun Biol, 6:649-649, 2023 Cited by PubMed: 37337079DOI: 10.1038/s42003-023-04990-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.74 Å) |
Structure validation
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